Dr Cyril Carroll (National University of Ireland, Galway)


Contact Details

Email: cyril.carroll@nuigalway.ie
Phone: 353 (0)91 492277 (ext. 2277).

Bio

Director of the Postgraduate Diploma in Applied Microbiology Programme.

Professional Profile:

  • Director of Postgraduate Diploma in Applied Microbiology since1992.
  • Course Director of the Genetics Module course (2004 -)
  • World Health Organisation Advisor at the WHO Consultation on ’The increased incidence of Human Campylobacteriosis’ (2000).
  • Member of the Microbiology Sub-Committee of the Food Safety Authority of Ireland (2000- present)
  • Member of the Scientific Advisory Committee on Animal Health and Welfare of the Department of Agriculture and Food.
  • Member of the Irish Health Research Board ’Infections, Immunity and Host Defence’ Research Awards Panel (2004 – present.)
  • Member of the RELAY Steering Group Committee for Department of Agriculture Food Institute Research Measure (2002 – present)
  • Member of the Scientific Committee for the European Union Science Olympiad (EUSO) held in the NUI Galway (2005)

Research Interests:

Detection and Epidemiology: Design and development of novel targets for use in nucleic acid based diagnostics assays for the detection of bacterial food pathogens.

Use of molecular methods (culture and DNA - based) for detection identificatiuon and epidemiological studies of bacterial food pathogens. Methods include: PCR, PFGE, RAPD, RFLP, Ribotyping, DNA sequencing.

Adaptive Tolerance Response in   Campylobacter spp.: Physiological stress response in bacteria and the effect of processing treatments of bacterial survival, virulence and gene expression. In particular the Adaptive Tolerance Response in Campylobacter spp. Methods include the use of proteomics and microarrays.

Study of selective antibiotic resistance mechanisms: Evaluation of the effect of sub-inhibitory concentrations of antibiotics on the selection of single and multiple drug resistance in bacterial pathogens.
  
Biofilms: Biofilm formation.

Bioactive Ingredients from Algal Sources: Assessment of the effects of the alginate and  laminaran extracts on intestinal flora. Novel Antimicrobial tools to limit Campylobacter infection of poultry

Recent Publications:

  • Duffy, K. and Carroll, C.V. (1996). The susceptibility of microaerophilic and aerotolerant variants of Campylobacter jejuni to various stresses. Society of General Microbiology Meeting, Galway, January 1996.

  • McGrath, Y., O’ Hici, B., Doyle, O., Flynn, J., and Carroll, C. V. (1997). The application of Typing Methods to Clinical Isolates of Campylobacter jejuni. Presented at the Annual Irish Geneticists Meeting, Dept. of Microbiology, University College Galway, April. 1997, p.31.

  • Duffy, K. S.,  and Carroll, C. V. (1997). Strategies towards the cloning and sequencing of the groELS genes of Campylobacter jejuni . Presented at the Annual Irish Geneticists Meeting, Dept. of Microbiology, University College Galway, April. 1997, p.11.

  • Duffy, K. S., Moran, A. P.,  and Carroll, C. V. (1997). Ultra Violet and Hydrogen Peroxide Sensitivity of Campylobacter jejuni ; a Comparison between a Microaerophilic strain and its Aerotolerant Variant Form. Presented at the 9th International Workshop on Campylobacter, Helicobacter and Related Organisms. Arthur's Seat hotel Cape Town, South Africa, 15 - 19 September 1997. F.2. p28.

  • Smith, P., Carroll, C.V., Wilkins, B., Johnson, P., Nic Gabhainn, S. and Smith, L. P. (1999). The effect of wind speed and direction on the distribution of sewage associated bacteria in Galway Bay. Letters in Applied Microbiology, 28 (3): 184-188.

  • O'Sullivan, N. A., Fallon, R., Carroll, C., Smith, T. and Maher, M. (2000). Detection and differentiation of Campylobacter jejuni and Campylobacter coli in broiler chicken samples using a PCR/DNA probe membrane based colometric detection assay. Molecular and Cellular Probes, 14 (1): 7-16.

  • Grennan, B., O'Sullivan, N.A., Fallon, R., Carroll, C., Smith, T., Glennon, M., and Maher, M. (2001). PCR-ELISA's for the detection of Campylobacter jejuni and Campylobacter coli in poultry samples. BioTechniques, 30 (3): 602 - 611.

  • Fallon, R.V., Doolan, I., O'Sullivan, N.A., Smith, T. and Carroll, C.V. (2001). Isolation of Campylobacter species from farm to fork in Ireland. International Journal of Medical Microbiology, 291: 38.

  • Fallon, R.V., Casey, E., Maher, M., Smith, T.  and Carroll, C.V. (2001). Characterisation of Campylobacter species isolated from broiler chickens by flagellin gene typing. International Journal of Medical Microbiology, 291: 66.

  • Murphy, C., Carroll, C. and Jordan, K.N. (2002) Induction of an adaptive tolerance response increases survival of Campylobacter jejuni in acidic foods. Irish Journal of Agriculture and Food Research 41: 124.

  • Murphy, C., Carroll, C. and Jordan, K.N. (2003) Novel mechanism of survival of Campylobacter jejuni due to environmental stresses. Irish Journal of Agriculture and Food Research. 42, 162-163.

  • McCarthy, D., O’Hagan, N., Glannon, M., Shkarlat, P., Carroll, C., Cormican, M. and Maher, M. (2003). Application of a PCR/DNA-probe colorimetric Assay to the investigation of floroquinolone resistance in Campylobacter jejuni.   International Journal of Medical Microbiology 293, 51.

  • Murphy, C., Carroll, C and Jordan, K.N. (2003) Extracellular signalling mechanism that increases Campylobacter jejuni survival of environmental stress. International Journal of Medical Microbiology 293, 59.

  • Murphy, C., Carroll, C. and Jordan, K.N. (2003) The role of an adaptive tolerance response in increased survival of Campylobacter jejuni during environmental stress. International Journal of Medical Microbiology 293, 59

    O’Rourke, M., Carroll, C., Maher, M. and Casey, E. (2003). Development and application of real-time quantitative RT-PCR assays for cadF and cdtB expression studies in Campylobacter. International Journal of Medical Microbiology 293, 83.

  • O’Leary A.M., Whyte, P., McGill, K., Cowley, D., Madden, R.,  Moran, L., Scates, P., Collins, J., and Carroll, C. (2003). Genetic heterogeneity of Campylobacter jejuni strains of clinical and food origin in Ireland determined by PFGE and flaA PCR RFLP analysis. International Journal of Medical Microbiology 293, 98.

  • Casey, E., Doolan, I., Whyte, P., and Carroll, C.. (2004). A comparison of genotypic methods for assessing strain diversity amongst thermotolerant Campylobacters isolated from broiler farms in Ireland. International Journal of Medical Microbiology 293, 101.

  • Canty, D., Fanning, S., Cormican, M., and Carroll, C.. (2003). Genotypic evidence of a relationship between Campylobacter jejuni and Campylobacter coli isolates from poultry and humans. International Journal of Medical Microbiology 293, 105.

  • Doolan, I., Casey, E., Whyte, P., Cowley, D., and Carroll, C. (2004).  Investigation of the prevalence of thermophilic Campylobacter in commercially produced broiler flocks in the Republic of Ireland. International Journal of Medical Microbiology 293, 137.

  • Fallon, R., O'Sullivan, N., Maher, M., and Carroll, C. (2003). Antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolates from broiler chickens isolated at an Irish poultry-processing plant. Letters in Applied Microbiology, 36 (5): 277–281.

  • Murphy, C., Carroll, C.., and Jordan, K. N. (2003). Induction of an adaptive tolerance response in the foodborne pathogen, Campylobacter jejuni. FEMS Microbiology Letters, 223 (1): 89-93.

  • Murphy, C., Carroll, C. and Jordan, K.N. (2003) Identification of a novel stress resistance mechanism in Campylobacter jejuni. Journal of Applied Microbiology 95 (4): 704-708.

  • Whyte, P., Mc Gill, K., Cowley, D., Carroll, C., Doolan, I., O'Leary, A., Casey E., and Collins, J. D. (2003).  A comparison of two culture media for the recovery of thermophilic campylobacters in broiler farm samples. Journal of Microbiological Methods, 54 (3): 367-371.

  • Maher, M., Finnegan, C., Collins, E., Ward, B., Carroll, C.., and Cormican, M. (2003). Evaluation of culture methods and a DNA probe-based PCR assay for detection of Campylobacter species in clinical specimens of feces. Journal of Clinical Microbiology, 41 (7): 2980-2986  

  • Fitzmaurice, J., Glennon, M., Duffy, G., Sheridan, J. J., Carroll, C.. and Maher. M. (2004). Application of real-time PCR and RT-PCR assays for the detection and quantitation of VT1 and VT2 toxin genes in E. coli 0157:H7. Molecular and Cellular Probes. 18 (2): 123-132.

  • P. Whyte, K. McGill, D. Cowley, R.H. Madden, L. Moran, P. Scates, C. Carroll, A. O’Leary, S. Fanning, J.D. Collins, E. McNamara, J.E. Moore, M. Cormican (2004). Occurrence of Campylobacter in retail foods in Ireland.  International Journal of Food Microbiology. 95 (2): 111-118

  • Fitzmaurice, J., Duffy, G., Kilbane, B., Sheridan, J. J., Carroll, C.. and Maher. M. (2004). Comparison of a membrane surface adhesion recovery method with an IMS method for use in a polymerase chain reaction method to detect Escherichia coli   0157:H7 in minced beef.  Journal of Microbiological methods, 59 (2): 243-252.

  • Murphy, C., Carroll, C. and Jordan, K.N. (2005). The effect of different media on the survival and induction of stress responses by Campylobacter jejuni.  Journal of Microbiological Methods, 62(2): 161-166

  • Murphy, C., Carroll, C., and Jordan, K.N. (2006). Environmental survival mechanisms of the foodborne pathogen Campylobacter jejuni, a review .  Journal of Applied Microbiology, 100: 623-632.

  • McGill, K., Cowley, D., Moran, L., Scates, P., O'Leary, A., Madden, R. H., Carroll, C., McNamara, E., Moore, J. E., Fanning, S., Collins, J.D., and Whyte P.  (2006).  Antibiotic resistance of retail food and human Campylobacter isolates on the island of Ireland from 2001-2002.  Epidemiology and Infection , 134 (6): 1282-1291.

Book Contributions

  • Duffy, K.S., Moran, A.P. and Carroll, C. V. (1998). Ultra violet and hydrogen peroxide sensitivity of Campylobacter jejuni; a comparison between a microaerophilic strain and its aerotolerant variant form.  In Lastovica, A. J., Newell, D. G. & Lastovica, E. E. (Eds.): Campylobacter, Helicobacter and Related Organisms. Institute of Child Health and University of Cape Town, Cape Town, South Africa. P.197-200.

  • Jennings, S.G., Moran, A.P. and Carroll C.V.. (2003). Bioaerosols and Biofilms.  In Biofilms in Medicine, Industry and Environmental Biotechnology; characteristics, analysis and control.  Eds Plens, Moran, A., Mahony, T., Stoodley, P. and O’Flaherty, V.  IWA Publishing, London UK.  Chapter 10: 160-178.

  • Jordan, K., Murph,y C and Carroll C.. (2005). Campylobacter spp. In “ Encyclopaedia of Diagnostic Genomics and Proteomics”.  Eds Jurgen Fuchs, Mauriziio Podda. Marcel Dekker Inc., New York. P. 185 – 188.

  • Carroll, C. (2006). New Infectious Disease Initiative at the National University of Ireland, Galway“Microbe-Human Interactions.” The Irish Scientist 2006 Year Book. (14), p 70

 

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