Diagnostic and Cell Surface Biochemistry
Our group has identified a family of novel carbohyrdrate binding proteins that are of keen interest
to the biopharmaceutical industry. This porjet would clone , purify mutagenise and characterise
these novel protein bioligands. Our novel ELLA analytical system (see recent publication below) will
be used to characterise these interesting bioligands. The project is a complimantary mix of protein
biochemistry and molecular biological techniques.
H. Alwael, D. Connolly, P. Clarke, R. Thompson, B. Twamley, B. O'Connor and B. Paull.
‘Pipette-tip selective extraction of glycoproteins with lectin modified gold nano-particles on a polymer monolithic phase’.
(2011) The Analyst , 136 , 2619-2628.
R. Thompson, A. Creavin, M. O’Connell, B. O’Connor, P. Clarke ‘Optimisation of the enzyme-linked lectin assay for enhanced glycoprotein
and glycoconjugate analysis’. (2011) Analytical Biochemistry , 413 , 2, 114-122.