Development of novel bioanalytical platforms for the Biopharmaceutical industry
This project will develop new bioanalytical platforms for the separtion of biopharmaceuticals. These platforms will be based on the immobilisation of novel recombinant protein bioligands (developed by our group) onto a variety of novel polymers (developed by our ISSC partners. There is a huge need for these bioanalytical systems in the emerging biopharmaceutical sector. The project spans three disciplines of protein chemistry, polymer chemistry and mirofluidics.
F. Audouin, M. Fox, R. Larragy, J. Huang, B. O’Connor and A. Heise ‘Polypeptide grafted macroporous PolyHIPE by surface initiated N- Carboxyanhydride Polymerization as a platform for bioconjugation’. (2012) Macromolecules [In press]
H. Alwael , D. Connolly , P. Clarke , R. Thompson , B. Twamley , B. O'Connor and B. Paull.
‘Pipette-tip selective extraction of glycoproteins with lectin modified gold nano-particles on a polymer monolithic phase’.
(2011) The Analyst , 136 , 2619-2628.