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Toxicology of engineered nanoparticles in target biological systems

University College Cork

Brief of Description of Project

Nanomaterials are an emerging group of 
environmental pollutants which are increasingly going
to be used in high‐quantity low‐value products. Thus, 
they are likely to appear in quantity in important 
environmental compartments such as the aquatic 
environment and soils. Nanoparticles are capable of 
crossing biobarriers and, in some cases, cause toxicity 
to cells and organisms. We have worked in recent 
years on metal NPs with the bivalve mollusc, Mytilus 
edulis and demonstrated that a key mechanism of 
toxicity in some cases is by oxidative stress. We also 
have an interest in the biotechnologically‐important 
yeast Trichoderma which shows strong resistance to 
metal toxicity. This project will apply redox proteomics
and other biomarkers such as lipid peroxidation to 
elucidation of metal toxicity in the case of defined 
nanoparticles (copper, zinc and iron oxide) in these 
target species in comparison to non‐toxic titanium 

Facilities and Research Environment

The Proteomics Research Group is located in a  modern purpose‐built building with allfacilitiesfor 2D electrophoresis and protein biochemistry. We have accesss to specialist labs for NP synthesis and MS analysis for protein identification.


Priority Areas

Principal Investigators

Research Groups